Roberto Menicagli
Dir RomaBiomedResearch Lab
Title: The Basic Knowledges About The Possibilty Of Employ The Micronucleus Test For The Diagnosis Of The Doubth Cases In The Screening For The Determination Of Breast Cancer
Submitted Date: 12-06-2017
Biography
Roberto Menicagli has completed his PhD at the age of 25 years from Milan University .Postdoctoral studies in biochemistry and molecular genetics, at the faculty of biology at Milan University. He is the director of Roma Biomed Research Lab a Private Medical Service Organization. Has published more than 20 papers in reputed journals ,some also with impact factor ; is also the principal author of 4 international patent ,in the field of the environment, and biomarkers , and has been serving as an editorial board member of two magazine concerning the medical sciences.
Abstract
INTRODUCTION AND OBJECTIVES : The aim of this study is to check the possibility to use the test with micronuclei in saliva, for cases doubts, detected in screening for breast cancerrnMATERIAL AND METHODS It is been executed a bibliographic search on Pub Med (MEDLINE) ,Home Genetic Reference, for articles published from Jan 1, 2000 to Dec 31, 2016,for the keywords : \"micronuclei in exfoliated buccal cells in breast cancer “ The key words are used in the research in free text, and with cross –referencing method application. Another search it is been made for “MN in breast cancer “,from Jan1 2014 to today.rn RESULTS Five studies show that in buccal cells, in breast cancer , the amount of MN are significantly higher than compared to benign cases as in six studies for the detection of micronuclei in needle aspirates ductal,. Contrasting results are for MN in peripheral blood lymphocytesrnDISCUSSION . The micronuclei scoring can be used as a biomarker on fine needle aspiration cytology smears of breast cancer, while the tests in peripheral blood lymphocytes , have known reproducibility problems .The references show also,that is an increase of MN in exfoliated buccal mucosa cells test, May be interesting to apply the MN scoring in cases of doubt, according to functional BI-RADS category 3 (probably benign), and which are sent to a successive controlrnCONCLUSIONS: it has verified that in buccal cells, in cases of breast cancer is significantly higher than the number of MN compared to benign cases, indicates the possibility of applying this technique in cases of doubt, in oral salivarn