^10th World Congress on Biomarkers & Clinical Research October 18-20, 2017 Baltimore, Maryland, USA

Conference Series LLC Ltd Conferences invites all the participants across the globe to attend ‘10th World Congress on Biomarkers and Clinical Research’ during October 18-20, 2017 in Baltimore, USA which includes prompt Keynote presentations, Oral talks, Poster presentations, Exhibitions & Sponsorship.

Biomarkers 2017 will mainly focus on the exploring new ideas in Biomarkers, Cancer Biomarkers, Molecular Biomarkers, types of biomarkers, Biomarkers in Clinical Research & Development, Biomarkers in drug discovery,  biomarkers disorders, Biomarkers in Pathology,  Functional genomics and cytogenetic biomarkers and its clinical research and development, Omics technologies  in discovery and its validation, biomarkers of exposure response and susceptibility, techniques to maximize biomarker identification, biomarkers Nano science.

Conference Series LLC Ltd, the host of this conference is comprised of 3000+ Global Events with over 600+ Conferences, 1200+ Symposiums and 1200+Workshops on diverse Medical, Pharmaceutical, Clinical, Engineering, Science, Technology, Business and Management field is organizing conferences all over the globe. Biomarkers conferences include scientific keynote lectures, symposia, workshops, exhibitions with the support from Oncology Society and American Oncology Society.

Track 1: Biomarkers Ltd

A biomarker, or natural marker, for the most part alludes to a quantifiable pointer of some organic state or condition. The term is additionally infrequently used to allude to a substance the nearness of which demonstrates the presence of a living being. Encourage, life structures are known to shed one of kind chemicals, including DNA, into the earth as proof of their nearness in a specific area. Biomarkers are regularly measured and assessed to look at ordinary natural procedures, pathogenic procedures, or pharmacologic reactions to a restorative mediation. Biomarkers are utilized as a part of numerous logical fields.

Track 2: Cancer Biomarkers

Growth (Cancer) biomarkers are utilized to distinguish the characteristic course of a tumour and are utilized to evaluate odds of creating disease. Biomarkers in growth screening assume an essential part in tumour identification and hazard evaluation to lessen malignancy passing’s. Tumour biomarkers are utilized to distinguish malignancy advancement and movement. Uterine cervical growth, endometrial disease, trophoblastic neoplasms and ovarian tumour are gynaecologic malignancies for which tumour markers are in clinical utilize. Viable disease biomarkers are utilized to decrease malignancy death rates by encouraging determination of tumours at early stages. Tumour biomarkers can likewise be utilized as a part of analysis, hazard evaluation and repeat of malignancy.

Types of cancer biomarkers

• Uses of biomarkers in cancer research
• Lung cancer biomarkers
• Prostate cancer biomarkers
• Breast cancer biomarkers
• Advanced biomarkers for Cancer

Track 2.1: Cancer Bioinformatics

Cancer bioinformatics is application of bioinformatics tools in the field of cancer treatment. Clinical bioinformatics an emerging study combining bioinformatics, clinical informatics, information technology, medical informatics, mathematic together which is related to cancer information.  Cancer bioinformatics may be considered to be one of the critical elements which address clinical challenges in early diagnosis, predictive prognosis of patients with cancer. The specificity, applicability, and integration of methodologies, computational tools, Cancer Clinical Trials Data Management Software, and databases which can be used to explore the molecular mechanisms of cancer and identify and validate network biomarkers, novel biomarkers, and individualized medicine in cancer. PAM50 centroid-based genomic predictors for breast cancer treatment plans and providing the uncertainty information in a usable way.

• Bioinformatics and Cancer
• Breast Cancer Now Tissue Bank bioinformatics portal (BCNTBbp)
• Pancreatic Expression Database (PED)
• SEARCHBreast
• SNPnexus
• O-miner
• Uses of biomarkers in cancer medicine

Track 3: Molecular Biomarkers

A biomarker can be anything that can be precisely measured as a pointer of ordinary organic working, pathogenic ways or a medication reaction to a restorative medication intercession. Atomic biomarkers are the biomarkers for the most part in sub-atomic frame. Atomic biomarkers partake in different purposes, including illness analysis and visualization, forecast and computation of treatment reaction, and wellbeing assessment. The atomic biomarkers are only being created and approved to be utilized as a part of medication improvement, and used to bolster endorsement of medication items.

Track 3.1: Molecular Biomarkers Discovery

Biomarker disclosure requires exceedingly guaranteed distinguishing proof of a biomarker particle with constant quantitative data to demonstrate which proteins are changing to a factually correlated degree in light of infection. The revelation of atomic biomarkers has grown new systems beginning from the underlying strides. In the main phase of biomarker disclosure procedures, examination relies on mass spectrometry systems to make unprejudiced, semi quantitative investigation of changes amongst solid and sick states. The slant of plausible sub-atomic biomarkers produced in the revelation stage is to be further substantiated because of the high false positive rate. It is done through supplemental more focused on and quantitative mass spectrometry procedures, for example, immuno fondness peptide enhancement.

New procedures for disclosure

• Protein biomarker revelation
• Clinical biomarker progresses
• Biomarkers for pediatric maladies
• Clinical examination of NGS tests
•  Mass spectrometry based biomarker revelation

Track 4: Biomarkers for Immuno-Oncology

Disease immunotherapy is the utilization of the safe framework to treat tumor. Immunotherapies can be ordered as dynamic, uninvolved or half and half. These methodologies abuse the way that growth cells frequently have atoms on their surface that can be distinguished by the resistant framework, known as tumor-related antigens, they are regularly proteins or different macromolecules (e.g. sugars).

Dynamic immunotherapy guides the resistant framework to assault tumor cells by focusing on TAAs. Latent immunotherapies upgrade existing against tumor reactions and incorporate the utilization of monoclonal antibodies, lymphocytes and cytokines.

Tracks 4.1: Personalized Immunotherapy

Powered with advances in genomic advances, customized oncology guarantees to develop disease treatment and target beforehand undruggable space. Improvements in customized tumor immunizations, supportive T-cell treatments, and biomarker-driven immuno-oncology clinical trials, are empowering the up and coming era of disease treatment. Cambridge Healthtech Institute's Second Annual Personalized Immunotherapy meeting unites clinical immuno-oncologists and thought pioneers from pharmaceutical and biotech organizations, and driving scholastic groups to share research and contextual analyses in actualizing understanding driven ways to deal with utilizing the safe framework to beat malignancy.

Tracks 4.2: Companion Diagnostics For Immunotherapy

The sidekick and correlative diagnostics for safe regulating treatments are entangled and require another methodical approach. Cambridge Healthtech Institute's Third Annual Companion and Complementary Diagnostics in Immuno-Oncology meeting is intended to unite clinical immuno-oncologists, analysts from pharmaceutical and biotech organizations, and individuals from the research facility medication group to talk about the hidden systems of malignancy immunotherapy, its prescient biomarkers and existing and developing clinical examines planning to enhance persistent results.

Tracks 4.3: Biomarkers to guide Immunotherapy

With late endorsements for numerous restorative antibodies that piece cytotoxic T lymphocyte related antigen 4 (CTLA4) and modified cell demise protein 1 (PD1) in melanoma, non-little cell lung tumor and kidney malignancy, and extra safe checkpoints being focused on clinically, many inquiries still remain in regards to the ideal utilization of medications that square these checkpoint pathways. Characterizing biomarkers that anticipate helpful impacts and unfavourable occasions is an essential order, highlighted by late endorsements for two PDL1 indicative tests. Here, we examine biomarkers for hostile to PD1 treatment in light of immunological, hereditary and virological criteria. The one of a kind science of the CTLA4 insusceptible checkpoint, contrasted and PD1, requires an alternate way to deal with biomarker improvement. Component based bits of knowledge from such reviews may manage the outline of synergistic treatment blends in view of insusceptible checkpoint bar.

Tracks 4.4: Clinical Trials for Cancer Immunotherapy

Quick improvements in growth immunotherapy are making chances to put up new blockbusters for sale to the public and requiring new clinical advancement procedures for quickening immuno-oncology clinical trials. Cambridge Healthtech Institute's Inaugural Clinical Trials for Cancer Immunotherapy meeting will concentrate on contextual investigations from continuous IO clinical trials, procedures for blend treatment clinical advancement, ID and approval of prescient and prognostic biomarkers for growth immunotherapy, and novel advances and methodologies to quicken IO clinical improvement.

Track 5: Biomarkers in Clinical Research & Development

The Biomarkers discovers its important application in the field of Clinical innovative work by contextual investigation and information administration as obvious through Biomarker meetings. The Bioethics and protected innovation right builds up the standards and standard of direct of theory concerning clinical approval of biomarkers. The fuse of biomarker in clinical trials for different illness conditions will advance a legitimate indicative and remedial approach using even the medicinal gadgets to recognize clinical biomarkers. Right now this is the blasting business. A large portion of the presumed associations like Pfizer, Parexel and Quintiles are into clinical innovative work. The organizations, doctor's facilities and clinical research associations are the problem areas for directing clinical research with its development rate expanding exponentially by an expected 75B$ by 2016.In clinical innovative work, clinical biomarkers are utilized as a part of contextual analysis and information administration, clinical trials and in therapeutic gadgets.

Track 6: Biomarkers and Drug Discovery

The part of Biomarkers in medication revelation and advancement is to comprehend the pathophysiology of ailment. Biomarkers can be a clinical instrument for medication disclosure and improvement by affirming the adequacy and security to the correct patient. Biomarkers can be utilized as a part of comprehension the instrument of medication.

Track 7: Biomarkers and Pathology

One imperative part of the part of Pathology in the assessment of bosom malignancy is biomarker trying, particularly the precise appraisal of the estrogen receptor (ER), progesterone receptor (PR), and Her2 status of a patient's bosom tumor. Biomarkers can be prognostic, prescient, or both. Prognostic biomarkers are free measures of forecast to such an extent that the nearness or nonappearance of the biomarker is connected with a patient's general clinical result (i.e., danger of repeat and mortality).

Track 7.1: Molecular Pathology

Molecular pathology is an emerging discipline within pathology which is concentrated in the study and conclusion of ailment through the examination of molecules within organs, tissues or bodily fluids. Molecular pathology imparts a few parts of practice with drug development, disease management strategies and is sometimes considered a crossover discipline. It is multi-disciplinary in nature and concentrates primarily on the sub-minute parts of diseases. A key consideration is that more accurate diagnosis is possible when the diagnosis is based on both the morphologic changes in tissues and on molecular testing of diseases like cancer. In this sub topics Molecular pathology is very useful in drug development and cancer. There are 5 associations and societies and the main association for Molecular Pathology is the Association of Molecular Pathology in USA. 78 universities are working on Molecular Pathology. Companies and hospitals around USA are associated with pathology. NIH has released $197,088 for Molecular Pathology research.

Track 7.2: Clinical Pathology

Clinical Pathology is a medical specialty that is concerned with the diagnosis of disease based on the laboratory analysis of bodily fluids. Clinical Pathology is one of the major classifications of Pathology. Clinical Pathology is accomplished through practical diagnosis of disease based on the laboratory analysis. Clinical Pathology so far covers the diagnostic testing, Implications of cancer patients, Prognostic value, clinical and non-clinical toxicology testing, Clinical finding of cancer and other disease. It emerges other subtopic like Neuropathology. The following topics are the latest research going on in clinical Pathology.

Track 8: Biomarkers for Disorders

Biomarkers are the trademark natural quantifiable indictors for the different issue if happening in strange levels. These are utilized as quantitative elements for neurological issue, hereditary scatters, metabolic disarranges, cardiovascular clutters and natural mistakes. The present time is concentrating on the tumor examine using biomarkers as indictor of infection conditions. The lung disease biomarkers and biomarkers for bosom malignancy are comprehensive of qualities, chemicals, proteins and cell surface entitles. Enrolling a compound yearly development rate of 14.60% from 2011 to 2018, the market for oncology biomarkers was esteemed at $13.16 billion in 2011 and is relied upon to be worth $29.78 billion in 2018.Biomarkers are additionally utilized as a part of diagnosing and treating different illnesses and scatters like Neurological issue, Genetic issue, Metabolic issue, Cardiac issue, Inborn blunders, Lung disease and Breast malignancy.

Track 9: Biomarker Discovery, Verification & Validation

As a rule, biomarker inquires about takes after a continuum that starts with disclosure and continues through approval to the possible execution of biomarkers in a clinical setting. Biomarker disclosure requires high certainty recognizable proof of biomarker applicants with concurrent quantitation data to demonstrate which proteins are changing to a factually significant degree in light of infection. Biomarker competitors distinguished in disclosure should be approved utilizing bigger example sets covering an expansive segment of patient companions. To maintain a strategic distance from a potential bottleneck connected with taking countless to approval, a confirmation step is utilized to screen potential biomarkers to guarantee that lone the most noteworthy quality leads from the disclosure stage are taken into the exorbitant approval arrange. The check arranges requires a high throughput work process with at least specimen planning that gives both high specificity and affectability. Also, the confirmation stage can affirm that a specific philosophy is reasonable to be utilized as a part of the approval stage.

Track 9.1: Mass spectrometry based biomarker discovery, verification, and validation

In its initial years, mass spectrometry (MS)- construct proteomics centered in light of the classifying of proteins found in various species or diverse tissues. By 2005, proteomics was being utilized for protein quantitation, normally in light of "proteotypic" peptides which go about as surrogates for the parent proteins. Biomarker disclosure is normally done by non-focused on "shotgun" proteomics, utilizing relative quantitation strategies to decide protein expression changes that connect with ailment (yield given as "up-or-down direction" or "crease increments"). MS-based systems can likewise perform "outright" quantitation which is required for clinical applications (yield given as protein fixations). Here we portray the contrasts between these strategies, figures that influence the exactness and precision of the outcomes and a few cases of late reviews utilizing MS-based proteomics to confirm malignancy related biomarkers.

Track 9.2: Protein Biomarker Discovery & Validation

Oncology biomarker research is about interpreting progress made in distinguishing pertinent biomarkers in essential research into malignancy therapeutics that possibly advantage patients. Our approach utilizes mass spectrometry as the revelation motor to find new oncogenic or tumorgenic biomarkers. Growth look into methods utilizing mass spectrometry can be utilized to find and approve biomarkers that can be utilized for early identification of malignancy, proteomics in tumor prognostics, proteogenomics and checking reaction to treatment.

Track 10: Personalized Medicine and Data Analysis

Recently there has been enhanced and advanced biomedical technology such as high-throughput molecular imaging and microarrays to monitor SNPs, gene and protein expressions, to provide exhaustive situations for individuals. The biological and medical status from such data sets, which are viewed as biomarkers in a wide sense to help to do identification, association, and prediction studies for phenotypes such as cancer subtypes, prognosis, treatment responsiveness, and adverse reactions for personalized medicine.

Track 11: Cancer Research

Growth research is fundamental research into tumor to recognize causes and create methodologies for aversion, analysis, treatment, and cure. Growth investigate ranges from the study of disease transmission, sub-atomic bioscience to the execution of clinical trials to assess and think about utilizations of the different malignancy medicines. These applications incorporate surgery, radiation treatment, chemotherapy, hormone treatment, immunotherapy and consolidated treatment modalities, for example, chemo-radiotherapy. Beginning in the mid-1990s, the accentuation in clinical disease explore moved towards treatments got from biotechnology research, for example, tumor immunotherapy and quality treatment.

Track 12: Clinical Research

Clinical research is a branch of social insurance science that decides the wellbeing and adequacy (viability) of solutions, gadgets, analytic items and treatment regimens expected for human utilize. These might be utilized for counteractive action, treatment, finding or for calming side effects of a sickness. Clinical research is unique in relation to clinical practice. In clinical practice built up medicines are utilized, while in clinical research confirmation is gathered to set up a treatment.

Track 12.1: Innovations in Pre-clinical Research

Pre-clinical research in like manner named pre-clinical audits and nonclinical studies is a period of research that begins before clinical trials, and in the midst of which basic credibility, iterative testing and drug security data is assembled. The rule targets of clinical research audits are to choose the shielded estimations for First-in-man study and start to overview thing's security profile. Things may fuse new or iterated or like-kind helpful contraptions, medications, et cetera.

Track 12.2: Design of Clinical Studies

Clinical audit arrangement is the meaning of trials and tests, and moreover observational surveys in helpful, clinical and diverse sorts of research including individuals. Clinical research are typically driven in four phases, each stage is considered as specific trial and, after complete of a phase, analysts are required to show their data for underwriting from the FDA before continuing to the accompanying stage. By sharing in clinical trials, individuals can't simply expect a more dynamic part in their own specific social protection, yet they can in like manner get to new solutions and help other individuals by adding to restorative research. Sorts of Study Designs Meta-Analysis, Systematic Review, Randomized Controlled Trial, Cohort Study, Comparative Study, Case-control Study, Cross-sectional audit, Case Reports and Series, Animal Research Studies, Test-tube Lab Research.

Track 13: Clinical Trials

Clinical trials are tests done in clinical research. Such imminent biomedical or behavioral research thinks about on human members are intended to answer particular inquiries regarding biomedical or behavioral mediations, including new medications, (for example, novel antibodies, drugs, dietary decisions, dietary supplements, and medicinal gadgets) and known intercessions that warrant additionally study and examination. Clinical trials produce information on security and viability.

Track 13.1: Conducts of Clinical Trials

Clinical trials also known as clinical research studies that follow a pre-defined plan or protocol. Researchers design clinical trials (Clinical study designs) to answer specific research questions related to a medical product. Clinical trials, particularly those looking at new drugs, often start after successful animal studies. The most promising treatments then move into clinical trials.

Track 14: Translational Biomarkers & Diagnostics

Translational prescription regularly alluded to as translational science, (of which it is a frame) is characterized by the European Society for Translational Medicine (EUSTM) as an interdisciplinary branch of the biomedical field bolstered by three primary columns: benchside, bedside and group. The objective of TM is to consolidate disciplines, assets, mastery, and strategies inside these columns to advance upgrades in aversion, analysis, and treatments. As needs be, TM is a very interdisciplinary field, the essential objective of which is to mix resources of different natures inside the individual columns keeping in mind the end goal to enhance the worldwide social insurance framework altogether.

Track 15: Biomarkers & its Diseases

Disease-related biomarkers give an indication of the probable effect of treatment on patient (risk indicator or predictive biomarkers), if a disease already exists (diagnostic biomarker), or how such a disease may develop in an individual case regardless of the type of treatment (prognostic biomarker). Predictive biomarkers help to assess the most likely response to a particular treatment type, while prognostic markers show the progression of disease with or without treatment, some diseases are:-

• Autoimmune disease
• Alzheimer's disease
• Cardiovascular disease
• Neurological Disorders
• Immunological Disorders

Track 16: Functional Genomics and Cytogenetic Biomarkers

The branch of genomics that determines the biological function and complex association of the genes and their products depicts the functional genomics. The measurable degree of these parameters through various processes and equipment inclusive of Next generation sequencing, Personalized genome sequencing and mi-RNA sequencing utilizing cellular entities to predict SNP biomarkers, immuno fluorescent biomarkers, oxidative stress biomarkers, si-RNA and mi-RNA will aid in better understanding of the disease outcome. The cytogenetic biomarkers are a feasible diagnostic tool to detect DNA and chromatin damage.

Track 17: Omics Technologies in Biomarkers Discovery and Validation

Biomarkers play a critical role in disease diagnosis and treatment, especially for the early detection of cancer, to enable screening of asymptomatic populations. Recent omics technologies, such as Transcriptomics, genomics and proteomics approaches besides Metabolomics are accelerating the rate of biomarker discovery. The incorporation of techniques like microarray data analysis, computational biology, data mining methods, Transcriptomics and profiling techniques are playing a crucial role in the validation of biomarkers. Since the Human Genome Project was completed in April 2003, genome-wide association studies (GWAS) have contributed toward a greater understanding of the genetic basis of complex diseases and advances in high-throughput technologies. This has enabled researchers to rapidly map the genome of vertebrates, invertebrates and pathogens through cost-effective methods.

Track 18: Techniques to Maximize Biomarker Identification

Biomarkers are the existing bimolecular and integral indictors of disease condition of biological systems. The techniques used to identify and maximize the expression of biomarkers include RT-PCR genotyping, molecular imaging and dynamics, biochemical  assay and profiling, immunological techniques and chromatographic techniques. A wider approach towards identification of biomarkers lies in the proteomic approach besides utilizing biosensors as a compatible tool for evaluation of biomarker levels in the biological systems. Most of the company’s focus is on generating cost effective durable profiling techniques and equipment to quantify biomarkers within a short span of time. Johnson & Johnson, GlaxoSmithKline Plc., GE Healthcare, Affymetrix Inc.

Track 19: Biomarkers and Pharmacology

In the biomarker pipeline, the technologies that will enable the use of biomarkers in drug discovery and development vary depending on the research stage. The second stage, biomarker validation and clinical assay development, depends upon extremely sensitive and specific high-throughput immunoassays. The single greatest challenge in discovering biomarkers with clinical utility is the sensitivity and specificity necessary to determine that a biomarker is truly positive for disease or disease toxicodynamics, and can be used to detect deviations from normal. The molecular biomarkers conferences provide good exposure in drug discovery. Biomarkers have special applications in the areas of translational medicine, clinical development and safety assessment where they are put through several stages of drug discovery, development and validation.

Track 19.1: Clinical Pharmacology

Clinical pharmacology is the basic science of pharmacology with an added focus on the application of pharmacological principles and methods in the medical clinic and towards patient care and outcomes.

Track 19.2: Environmental Pharmacology

Center is being given to comprehend gene–environment cooperation, medicate environment communication and poison environment association. There is a nearby coordinated effort between ecological science and prescription in tending to these issues, as social insurance itself can be a reason for natural harm or remediation. Human wellbeing and environment are personally related. Interest for more pharmaceutical items may put the general population at hazard through the pulverization of species. The passage of chemicals and medications into the oceanic environment is a more genuine concern today.

Track 19.3: Pharmacogenomics

Pharmacogenomics is the application of genomic technologies to drug discovery and further characterization of older drugs.

Track 20: Case Reports

A case report is an elaborated report of the symptoms, signs, disease diagnosis, treatment, and follow-up of an individual patient usually recorded in medical field. Case reports might comprehend a demographic profile of the patient, but typically mention any unusual or unique occurrences. In this conference case reports on biomarker diagnostics, drug discovery and imaging are discussed in detail in relevance to molecular and cancer biomarkers. Cancer biomarkers conferences are a big platform to study case reports of these in precision.

Track 21: Biomarkers: Entrepreneur Investments Meet

A key ingredient in successful entrepreneurship is self-knowledge. Biomarkers-2017 aims to bring together all existing and budding bio entrepreneurs to share experiences and present new innovations and challenges in cancer community. Each year, over a million companies are started in the world with about 5–10 of them classified as high technology companies. Turning ideas into business ventures is tricky and the opportunity-recognition step is critical in new venture creation. This gestalt in the entrepreneur's perception of the relationship between the invention and final product is refined into a business model that describes how the venture will make money or provide an appropriate return to the potential investors. Cancer science is complex and rapidly changing and requires a specialized knowledge to understand the value of the innovation and its competitive position in the industry. This three day community-wide conference will be a highly interactive forum that will bring experts in areas ranging from Biomarkers to signalling pathways to novel therapeutic approaches to the scientific hub.