Biography
Biography: N S Neki
Abstract
A biomarker is a substance used as an indicator of a biological state. With the increase in prevalence of coronary artery disease, early diagnosis and management of acute coronary syndromes and myocardial infarction (MI) as well as risk stratification and prognostication is of utmost importance. Hence there is need of cardiac biomarkers. Cardiac biomarkers are very useful in a non diagnostic ECG which is observed in 50% cases. Amongst various cardiac biomarkers, CPK-MB and Troponins (T & I) are the markers of choice for detecting myocardial dysfunction since other cardiac markers may be elevated in muscle injury, kidney and liver disease. Troponins are commonly used in the diagnosis of acute coronary events and myocardial damage because of high specificity and sensitivity, thus detecting myocardial injury in patients presenting late. They have replaced CPK-MB for diagnosis of MI. The levels of Troponin are increased within 4-8 hours after the onset of chest pain reaching peak concentration in 12-24 hours and remaining elevated for 4-10 days following acute MI. Although no ideal biomarker exists, yet Troponins fulfill most of the criteria of ideal biomarker. However false elevation of Troponins level may occur in pulmonary embolism, non-ischemic cardiac disorders, sepsis, stroke , trauma , internal bleeding, renal failure, hypovolemia, atrial fibrillation, congestive heart failure, myocarditis etc. So one should be aware of these non-ACS conditions. However abnormal values may be interpreted carefully in the proper clinical interest.
Speaker Presentations
Speaker PPTs Click Here