Wassil Nowicky
Ukrainian Anti-Cancer Institute, Austria
Title: Angiogenic properties of NSC-70 (UKRAIN/NSC-631570)
Biography
Biography: Wassil Nowicky
Abstract
Another important feature of NSC-631570 is the inhibition of the formation of the new blood vessels supplying a tumor. Due to these antiangiogenic properties NSC-631570 administered before surgery brings about better demarcation of the tumor from surrounding tissue and the tumor encapsulation. This alleviates the surgical removal of tumors what has been confirmed in breast cancer studies [67, 71, 103-106, 140]. In tests in vitro, NSC-631570 inhibited in a dose-dependent manner the proliferation of human endothelial cells without exerting cytotoxic effect. The angiogenesis inhibition was observed on the capillary formation model [134]. This inhibition of the neoangiogenesis prevents the metastasis formation as well.
The length of the total capillary tubes after the incubation with NSC-631570 in given concentrations. 1 – HUVEC were incubated with NSC-631570 for 4 h. 2 – HUVEC were preincubated with NSC-631570 for 4h and then incubated for 2 h in fresh medium without NSC-631570. HUVEC – human umbilical vein endothelial cells