Saganuwan Alhaji
University of Agriculture, Nigeria
Title: Derivation of a unique body surface area (BSA) formula for calculation of relatively safe doses of dog and human anticancer drugs
Biography
Biography: Saganuwan Alhaji
Abstract
The safety of anticancer dosing has become a serious concern due to high incidence of life-threatening toxicity signs. More so, dogs are used as models of research for human cancers. As such, a uniform body surface area (BSA) formula is developed for human and dogs with a view to having low safe effective therapeutic doses of anticancers.. The derived formula (BSA=BW0.528×H0.528×K) was used to calculate BSAs of greyhound, toy, companion, terrier, hunting and working dogs, yielded low doses of dacarbazine, asparaginase, streptozotocin, dactinomycin, epirubicine and prednisolone. Hunting and working dogs have high body weight, BMI and BSAs similar to that of human and may be prone to obesity and obesity associated diseases. Whereas BSAs and doses of anticancer agents of light and relatively tall dogs are relatively higher in comparison with that of short and light dogs. Greyhounds have higher BSA in comparison with toys, companions and terriers. Working breeds of dog: treeing walker coon haired (65.0 kg), great swiss mountain dog (59.0 kg), longhaired St bernard (55.0 kg), french mastiff (50.0 kg) and female komondor (59.0 kg) have same BSA values with humans weighing 51.3, 46.7, 44.8, 44.0 and 43.0 kg, respectively. Calculated exponent (0.528) may be the common relationship between basal metabolism of dog and human.