Hajime Orita
Shizuoka Hospital-Juntendo University, Japan
Title: The efficacy of Gasdermin gene family for tumor marker in colorectal cancer
Biography
Biography: Hajime Orita
Abstract
Gasdermin (Gsdm) family was originally identified as a candidate causative gene for mouse hair follicles, recombination-induced mutation 3 (Rim3). It has four human homologs; A, B, C, and D. All Gsdm family members are located in amplicons; genomic regions often amplified during cancer development, and are considered to be involved in the regulation of epithelial apoptosis. Gsdm A is mainly expressed in the upper gastrointestinal tract. In contrast, Gsdm D is expressed in the colorectal tract. In this study, we researched those expressions in colorectal cancer and evaluated them for tumor marker, comparing between those expression and clinical pathological status. We analyzed expressions of Gsdm A and D, using thirty colorectal cancer cases which were surgically treated at our institution 2013（Stage I; 10 cases　Stage II; 10 cases and Stage III; 10cases. Then retrospective analysis of the connection, between Gsdm expression and clinic-pathological data was done. GsdmA is not expressed in normal colorectal epithelium, but is overexpressed and gradually-rising in carcinoma, meanwhile, GsdmD showed precisely the opposite results. The results of the expression analysis suggest that GsdmA and GsdmD works parallel, and relate to clinical stage.