Biomarkers, Cancer Therapy & Clinical Research

Biomarker Detection Technologies

Biomarker detection technologies are fundamental to the identification and quantification of molecular indicators that inform disease diagnosis, prognosis, and therapeutic response. These technologies employ advanced analytical and molecular techniques to detect biomarkers across a wide range of biological samples, supporting accurate clinical decision-making and improved patient care. Immunoassays, including enzyme-linked immunosorbent assays (ELISA) and Western blotting, are extensively used for protein biomarker detection due to their high sensitivity and specificity. Molecular technologies such as polymerase chain reaction (PCR) and next-generation sequencing (NGS) enable precise identification of genetic biomarkers, providing insights into disease-associated mutations and genomic variations, particularly in cancer and inherited disorders. Mass spectrometry is a cornerstone of proteomic analysis, allowing comprehensive protein identification and quantification in complex biological samples, thereby supporting biomarker discovery and validation. In addition, microarray and multiplex platforms facilitate high-throughput profiling of multiple biomarkers simultaneously, advancing personalized and precision medicine.