Biomarkers, Cancer Therapy & Clinical Research

Biomarkers of Exposure Response and Susceptibility

Biomarkers of exposure are important in toxicology, because they are an indicator of internal exposure and genetic susceptibility to drug, chemicals or the amount of chemical exposure that got accumulated in the body. Significant advances have been made in developing analytical methods that detect and quantify many natural or synthetic toxins or their breakdown products in the biological matrix. The ability to accurately measure biomarkers of exposure depends upon an adequate understanding of the chemistry and toxicology of the substance under consideration. Epigenetic biomarkers also quantify the degree of exposure to toxic dynamic and pharmacodynamics parameters in pathological and biochemical changes occurring due to exposure to harmful agents, brought to light by toxic dynamics meetings and pharmacodynamics workshops. This emerging field of study is gaining importance in industry with an estimate of more than 7,287 personnel conducting study across the globe. While studying the response and susceptibility parameters like toxic dynamic and pharmacodynamic parameters are taken into consideration to measure the internal exposure and genetic susceptibility to drugs and chemicals.